Research
ABOUT BNCT
Boron Neutron capture therapy (BNCT) is radiation therapeutics for treating locally tumors without major operation.
A drug containing boron (10B, the mass number is 10), which is easy to be incorporated into a cancer tissue, is administered to a patient. When thermal neutrons are irradiated into the patient, the nuclear reactions of 10B are caused as follows:
10B + n → α + 7Li
The α-rays (4He) and the lithium nuclei (7Li), which are released from the 10B, kill cancer cells effectively. Since the ranges of the α-rays and the lithium nuclei correspond approximately to the size of one cell. Therefore, only cells containing boron are killed, and the damage effects of surrounding normal cells are hardly caused.
Most of BNCT treatment results so far have been performed at research nuclear reactors as the sources of thermal neutrons. In recent years, the developments of the next accelerator based neutron sources for the BNCT are underway worldwide.
We develop the accelerator based neutron source for the BNCT with a liquid lithium target technology.
Development of a Next-Generation Cancer Treatment System(BNCT) -Osaka University
A feasibility design study on a neutron spectrometer for BNCT (Boron Neutron Capture Therapy)
Neutrons generated by accelerators have various energy spectra. Especially, the neutron spectrum in the epithermal region is important in BNCT facility. However, there are a few measurement methods for the neutron spectrum.
We have studied a new neutron spectrometer with a liquid moderator, which can estimate more accurate neutron spectrum by using an unfolding technique.
Study on measuring device arrangement of array-type CdTe detector for BNCT-SPECT
We study a SPECT system for the BNCT, named “BNCT-SPECT”. This is a three dimensional imaging device to monitor the local BNCT dose (the treatment effect) around the tumor in real time. The principle of the BNCT-SPECT is shown in Fig. 1. The boron neutron capture reaction is expressed as follows.
10B + n → a + 7Li + 2.79 MeV (6.1%)
→ a + 7Li?+ 2.31 MeV + 'Y (478 keV) (93.9%)
94% of residual 7Li is in the ?rst excited state, i.e., 7Li*. 7Li* decays in its half-life of 10?14 s and subsequently emits a 478 keV gamma-ray through the transition from the ?rst excited state to the ground state. We have developed the BNCT-SPECT to measure the intensity 3-D distribution of 478 keV gamma-rays from the tumor. We have investigated the feasibility of the BNCT-SPECT system by simulations with MCNP5. The BNCT system was composed of an array-type CdTe detector, a collimator, shielding blocks, and the walls of an irradiation room.
Fusion neutron engineering (fusion neutronics)
OKTAVIAN was built at Osaka University and has been operated since 1981 as an intense deuterium-tritium (D-T) neutron source at 1.5-ns pulses of 103 D-T neutron/pulse or as the maximum continuous neutron source of 3×1012 D-T neutron/s. This facility has been devoted mainly to studies on fusion neutron-related subjects by many researchers and has also served for international collaborations. OKTAVIAN consists of a high-current deuteron beam accelerator for D-T neutron production. Many fusion neutronics experiments have been carried out for the fundamental study of D-T fusion neutron transport characteristics. They have served to improve the evaluated nuclear data files and to test the calculation methods for fusion reactor designs.
Results
Publications
2023
K. Tochitani, K. Tomiyoshi, T. Inoue, F. Kamisaki, M. Matsuki, K. Hiramatsu, K. Aoki, S. Kusaka, S. Tamaki, F. Sato, I. Murata, "Response control of RPLGD for gamma-ray dose measurement using lead filters for BNCT", Applied Radiation and Isotopes, 199, 110897 (2023).
Yulin Ge, Yao Zhong, Nan Yuan, Yanbing Sun, Zhen Yang, Wei Ma, Liping Zou, Isao Murata, Liang Lu, "Optimization of moderator materials by NSGA II based on macroscopic cross-sections: applications in accelerator neutron sources", Journal of Instrumentation, 18, P08004 (2023).
Masataka Teshigawara, Eiji Takada, Shuhei Sumida, Kouji Shinohara, Takeo Nishitani, Sangaroon Siriyaporn, Longyong Liao, Kunihiro Ogawa, Mitsutaka Isobe, Shigeo Matsuyama, Misako Miwa, Sho Toyama, Isao Murata, Shingo Tamaki, Sachie Kusaka, "Development of Directional 14 MeV-Fusion Neutron Detector Using Liquid-Scintillator-Filled Capillaries", Electronics, 12(15), 3219 (2023).
Sota Araki, Kazuki Fukui, Indah Rosidah Maemunah, Rio Miyazawa, Shingo Tamaki, Sachie Kusaka, Isao Murata, "Design study of benchmark experiment for large-angle scattering cross section for non-solid target with 14 MeV neutron", EPJ Web of Conferences, 284, 07003 (2023).
Indah Rosidah Maemunah, Sota Araki, Rio Miyazawa, Kazuki Fukui, Shingo Tamaki, Sachie Kusaka, Dwi Irwanto, Abdul Waris, Zaki Su’ud, Fuminobu Sato, Isao Murata, "A benchmark study of large-angle neutron scattering cross section of tungsten using two shadow bars technique at 14 MeV", EPJ Web of Conferences, 284, 07002 (2023).
Isao Murata, Shingo Tamaki, Sachie Kusaka, Indah Rosidah Maemunah, Fuminobu Sato, Hiroyuki Miyamaru, Shigeo Yoshida, "Neutronics Design of Fusion Reactor–Based Boron Neutron Capture Therapy in ITER", Fusion Science and Technology, pp. 465-475 (2023).
Siriyaporn Sangaroon, Kunihiro Ogawa, Mitsutaka Isobe, Longyong Liao, Makoto Inami Kobayashi, Sho Toyama, Misako Miwa, Shigeo Matsuyama, Hirokuni Yamanishi, Shingo Tamaki, Isao Murata, Eiji Takada, Guoqiang Zhong, Apiwat Wisitsorasak, Nopporn Poolyarat, "Characterization of CLYC7 Scintillation Detector in Wide Neutron Energy Range for Fusion Neutron Spectroscopy", IEEE Transactions on Instrumentation and Measurement, 72, pp. 1-12 (2023).
K. Ogawa, M. Isobe, C. Weiss, E. Griesmayer, S. Sangaroon, E. Takada, S. Masuzaki, H. Ohtani, L. Liao, S. Tamaki, I. Murata, M. Osakabe, "Fusion product diagnostics based on commercially available chemical vapor deposition diamond detector in large helical device", Journal of Instrumentation, 18, P01022 (2023).
2022
Sachie Kusaka, Yumi Miyake, Yugo Tokumaru, Yuri Morizane, Shingo Tamaki, Yoko Akiyama, Fuminobu Sato, Isao Murata, "Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging", Life, 12(11), p. 1786 (2022).
Tatsuya Furuno, Takanobu Doi, Kanako Himi, Takahiro Kawabata, Satoshi Adachi, Hidetoshi Akimune, Shiyo Enyo, Yuki Fujikawa, Yuto Hijikata, Kento Inaba, Masatoshi Itoh, Shigeru Kubono, Yohei Matsuda, Isao Murata, Motoki Murata, Shintaro Okamoto, Kosuke Sakanashi, Shingo Tamaki, "Measurement of 12C(n,n’) reaction cross section to determine triple-alpha reaction rate in high-density environments", EPJ Web of Conferences, 260, 11010 (2022).
Sachie Kusaka, Yuri Morizane, Yugo Tokumaru, Shingo Tamaki, Indah Rosidah Maemunah, Yoko Akiyama, Fuminobu Sato, Isao Murata, "Cerebrospinal fluid-based boron delivery system may help increase the uptake boron for boron neutron capture therapy in veterinary medicine: A preliminary study with normal rat brain cells", Research in Veterinary Science, 148, pp. 1-6 (2022).
Hikari Nishimura, Moe Shinohara, Takaaki Miyoshi, Nikolaos Voulgaris, Sachie Kusaka, Shingo Tamaki, Fuminobu Sato, Isao Murata, "Experimental verification of real-time gamma-ray energy spectrum and dose monitor", Applied Radiation and Isotopes, 185, p. 110226 (2022).
Sachie Kusaka, Yuri Morizane, Yugo Tokumaru, Shingo Tamaki, Indah Rosidah Maemunah, Yoko Akiyama, Fuminobu Sato, and Isao Murata, "Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation for BNCT in a Rat Melanoma Model", Biology, 11(3), p. 397 (2022).
Yumi Miyake, Sachie Kusaka, Isao Murata, Michisato Toyoda, "Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging of L-4-Phenylalanineboronic Acid (BPA) in a Brain Tumor Model Rat for Boron Neutron Capture Therapy (BNCT)", Mass Spectrometry, 11(1), p. A0105 (2022).
Shingo TAMAKI, Fajar PANUNTUN, Kazumichi UEDOI, Haidong WANG, Sachie KUSAKA, Yuichiro MANABE, Yoko AKIYAMA, Teruya TANAKA, Fuminobu SATO, Isao MURATA, "Radioactivation Analysis of Concrete Wall in OKTAVIAN Facility", Plasma and Fusion Research, 17, p. 1405001 (2022).
Isao Murata, Sachie Kusaka, Kentaro Minami, Nobuhide Saraue, Shingo Tamaki, Itsuro Kato, Fuminobu Sato, "Design of SPECT for BNCT to measure local boron dose with GAGG scintillator", Applied Radiation and Isotopes, 181, p. 110056 (2022).
2021
K. Ogawa, M. Isobe, S. Sangaroon, E. Takada, T. Nakada, S. Murakami, J. Jo, G. Q. Zhong, Yipo Zhang, S. Tamaki, I. Murata, "Time-resolved secondary triton burnup 14 MeV neutron measurement by a new scintillating fiber detector in middle total neutron emission ranges in deuterium large helical device plasma experiments", AAPPS Bulletin, 31, 20 (2021).
Ryota Yamauchi, Shingo Tamaki, Yuri Morizane, Sachie Kusaka, Yuichiro Manabe, Yoko Akiyama, Fuminobu Sato, Isao Murata, "Feasibility study on image reconstruction for single-photon emission computed tomography with limited projections by neural networks", Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 986, p. 164700 (2021).
Atsuki Yamaguchi, Kazuki Fukui, Yuki Fujiwara, Shingo Tamaki, Sachie Kusaka, Fuminobu Sato, Isao Murata, "Benchmark experiment of large-angle scattering reaction cross section of iron at 14 MeV using two shadow bars – Comparison of experimental results with ENDF/B-VIII –", Journal of Nuclear Science and Technology, 58(1), pp. 80-86 (2021).
2019
T. Nishitani, Y. Arikawa, H. Kishimoto, I. Murata, K. Ogawa, N. Pu, M. Isobe, "Development of capillary plate neutron detector filed with liquid scintillator by using recoiled-particle trajectory analyses", Journal of Instrumentation, 14 (2019).
X.C. Guan, Y. Gong, I. Murata, T.S. Wang, "The new design and validation of an epithermal neutron flux detector using 71Ga(n,γ)72Ga reaction for BNCT", Journal of Instrumentation, 14 (2019).
S. Tamaki, K. Omura, T. Nishida, S. Kusaka, F. Sato, I. Murata, "Performance test of liquid-moderator-based neutron spectrometer for BNCT: Mono-energetic and spontaneous fission spectrum neutron measurements", Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Volume 940, pp. 435-440 (2019).
Yusuke Kashiwagi, Kazushi Aoki, Shingo Tamaki, Xingcai Guan, Sachie Kusaka, Fuminobu Sato, Isao Murata, "Development of epi-thermal neutron beam intensity detector with 71Ga(n,γ)72Ga reaction for boron neutron capture therapy", Applied Radiation and Isotopes, 151, pp. 145-149 (2019).
Qiang Wang, Yafei Han, Bingjun Chen, Zhenglin Huang, Shingo Tamaki, Isao Murata, Tieshan Wang, Kaihong Fang, "Cross sections of (n,x) reactions on cerium isotopes induced by D-T neutrons", Applied Radiation and Isotopes, 147, pp 144-151 (2019).
Taichi Hashimoto, Fuminobu Sato, Shingo Tamaki, Sachie Kusaka, Hiroyuki Miyamaru, Isao Murata, "Fabrication of radiophotoluminescence dosimeter with 3D-printing technology", Radiation Measurements, 124, pp. 141-145 (2019).
Fuminobu Sato, Taichi Hashimoto, Shingo Tamaki, Sachie Kusaka, Hiroyuki Miyamaru, Isao Murata, "One-dimensional dose measurement with string-shaped photo-stimulated luminescence detector", Radiation Measurements, 124, pp. 137-140 (2019).
E. Takada, T. Amitani, A. Fujisaki, K. Ogawa, T. Nishitani, M. Isobe, J. Jo, S. Matsuyama, M. Miwa, I. Murata, "Design optimization of a fast-neutron detector with scintillating fibers for triton burnup experiments at fusion experimental devices", Review of Scientific Instruments, 90, p. 043503 (2019).
Kohki KUMAGAI, Teruya TANAKA, Takuya NAGASAKA, Juro YAGI, Takashi WATANABE, Gaku YAMAZAKI, Fuminobu SATO, Shingo TAMAKI, Isao MURATA, Satoshi FUKADA, Kazunari KATAYAMA, Akio SAGARA, "Tritium Release from Molten FLiNaBe under Low Flux Neutron Irradiation", Plasma and Fusion Research, 14, p. 1405044 (2019).
2018
Jungmin Jo, MunSeong Cheon, Junghee Kim, Soobin Lim, M. Isobe, K. Ogawa, T. Nishitani, Seugil Park, I. Murata, Kyoung-Jae Chung, Y. S. Hwang, "Initial operation results of NE213 scintillation detector for time-resolved measurements on triton burnup in KSTAR", Review of Scientific Instruments, 89, 10, p. 118 (2018).
Kunihiro Ogawa, Mitsutaka Isobe, Takeo Nishitani, Eiji Takada, Hiroki Kawase, Tatsuki Amitani, Neng Pu, Jungmin Jo, MunSeong Cheon, Junghee Kim, Misako Miwa, Shigeo Matsuyama, Isao Murata, "High detection efficiency scintillating fiber detector for time-resolved measurement of triton burnup 14 MeV neutron in deuterium plasma experiment", Review of Scientific Instruments, 89, 10, p. 101 (2018).
Fuminobu Sato, Yasuhide Toyota, Naoki Zushi, Kikuo Shimizu, Yuka Miyamoto, Takayoshi Yamamoto, Toshiyuki Iida, Isao Murata, "Synthesis and characterization of spherical radiophotoluminescence glass detectors by melting method", Radiation Measurements, 113, pp. 1-6 (2018).
Fuminobu Sato, Taichi Hashimoto, Shingo Tamaki, Sachie Kusaka, Hiroyuki Miyamaru, Isao Murata, "Development of string-shaped radiophotoluminescence dosimeter for high-radiation field", Radiation Measurements, 111, pp. 1-5 (2018).
Shingo Tamaki, Sachie Kusaka, Fuminobu Sato, Isao Murata, "DESIGN IMPROVEMENT OF A LIQUID-MODERATOR-BASED NEUTRON SPECTROMETER FOR BNCT", Radiation Protection Dosimetry, 180, 1-4, pp. 300–303 (2018).
Kohki KUMAGAI, Teruya TANAKA, Juro YAGI, Takashi WATANABE, Fuminobu SATO, Shingo TAMAKI, Isao MURATA, Akio SAGARA, "Control of Chemical Forms of Tritium in FLiNaK under Low Flux Neutron Irradiation, Plasma and Fusion Research", 13, p. 3404071 (2018)
Kohki Kumagai, Teruya Tanaka, Juro Yagi, Takashi Watanabe, Fuminobu Sato, Shingo Tamaki, Isao Murata, Akio Sagara, "Tritium release from molten salt FLiNaK under low flux neutron irradiation with an AmBe neutron source", Fusion Engineering and Design, 136, pp. 1269-1272 (2018).
Naoya HAYASHI, Seiki OHNISHI, Yuki FUJIWARA, Sachie KUSAKA, Fuminobu SATO, Isao MURATA, “Optimization of Experimental System Design for Benchmarking of Large Angle Scattering Reaction Cross Section at 14MeV Using Two Shadow Bars”, Plasma and Fusion Research, 13, 2405002, 4p (2018).
Isao MURATA, Shingo TAMAKI, Yuki OTANI, Yuta OHSAWA, Yusuke KASHIWAGI, Sachie KUSAKA, Fuminobu SATO, “Techniques to Measure Absolute Neutron Spectrum and Intensity for Accelerator Based Neutron Source for BNCT”, Plasma and Fusion Research, 13, 2501007, 5p (2018).
Fuminobu Sato, Taichi Hashimoto, Shingo Tamaki, Sachie Kusaka, Hiroyuki Miyamaru, Isao Murata, “Development of string-shaped radiophotoluminescence dosimeter for high-radiation field”, Radiation Measurements, 111, pp. 1-5 (2018).
橋本泰一、山地恒輔、佐藤文信、宮丸広幸、村田勲、“ファイバ型ラジオフォトルミネセンス線量計の開発”、ESI-NEWS, 36[1], pp.1-7(2018).
2017
Tomonori Okumura, Tatsuro Maekawa, Naoki Zushi, Fuminobu Sato, Kikuo Shimizu, Yushi Kato, Isao Murata, Takayoshi Yamamoto, Toshiyuki Iida, “Measurement of Spatial Dose Distribution of High Radiation Field by Radiophotoluminescence Photography”, Rad. Safety Managemnent, 16, pp.13-19 (2017).
Xingcai Guan, Isao Murata, Tieshan Wang, “Monte Carlo Optimization of An Epithermal Neutron Flux Monitor for BNCT”, J. Nucl. Sci. Technol., 54[10], pp. 1118-1122 (2017).
Mina Kobayashi, Fuminobu Sato, Isao Murata, “Feasibility Study on Real-Time γ-Ray Spectrum / Dose Measurement System”, Trans. Am. Nucl. Soc., 116, pp. 985-998 (2017).
S. Tamaki, F. Sato, I. Murata, “Study on a liquid-moderator-based neutron spectrometer for BNCT ? Development and experimental test of the prototype spectrometer”, Nucl. Instrum. Meth. A870, pp.90-96 (2017).
Xingcai Guan, Masanobu Manabe, Shingo Tamaki, Fuminobu Sato, Isao Murata, Tieshan Wang, “Performance testing of the neutron flux monitors from 10 keV to 1 MeV developed for BNCT: A preliminary study”, Applied Radiation and Isotopes, 125, pp.119-123 (2017).
X. Guan, I. Murata, T. Wang, “Performance verification of an epithermal neutron flux monitor using accelerator-based BNCT neutron sources”, J. Instrum., 12, P09013 (2017).
Yuta Osawa, Shoichi Imoto, Sachie Kusaka, Fuminobu Sato, Masahiro Tanoshita, Isao Murata, “Development of An Epi-thermal Neutron Field for Fundamental Researches for BNCT with A DT Neutron Source”, EPJ Web of Conferences 153, 04008, 9p (2017).
K. Hiramatsu, S. Yoshihashi, S. Kusaka, F. Sato, E. Hoashi, I. Murata, “Gamma-Ray Dose Measurement with Radio-Photoluminescence Glass Dosimeter in Mixed Radiation Field for BNCT”, EPJ Web of Conferences 153, 04009, 9p (2017).
Mina Kobayashi1, Fuminobu Sato, Sachie Kusaka, Isao Murata, “Feasibility study on real-time γ-ray spectrum / dose measurement system”, EPJ Web of Conferences 153, 07014, 6p (2017).
Isao Murata, Masayuki Ohta, Sachie Kusaka, Fuminobu Sato, Hiroyuki Miyamaru, “Thought Experiment to Examine Benchmark Performance for Fusion Nuclear Data”, EPJ Web of Conferences 153, 07015, 6p (2017).
前川達郎、狩場友治、山地恒輔、日下祐江、佐藤文信、加藤裕史、村田勲、“ゾル－ゲル法によって調整されたホウ素含有Al2O3線量計の特性評価”、日本放射線安全管理学会誌、第16巻1号、pp.25-28 (2017).
田中憲一、梶本剛、遠藤暁、櫻井良憲、田中浩基、高田卓志、村田勲、玉置真悟、“イメージングプレートを用いた中性子捕捉療法ビーム成分分布の品質保証”、放射線、43巻、pp. 3-7(2017).
守實友梨、日下祐江、三宅陽治、佐藤文信、村田勲、”条件付確率を用いた簡易なBNCT用SPECT装置の画像再構成“、ESI-NEWS, 35[5], pp.7-16 (2017).
K. Ogawa, T. Nishitani, M. Isobe, I. Murata, Y. Hatano, S. Matsuyama, H. Nakanishi, K. Mukai, M. Sato, M. Yokota, T. Kobuchi, T. Nishimura, and M. Osakabe, "Investigation of irradiation effects on highly integrated leading edge electronic components of diagnostics and control systems for the LHD deuterium operation", Nucl. Fusion, 57, 086012(2017).
Fuminobu Sato, Tatsuro Maekawa, Tomoharu Kariba, Sachie Kusaka, Teruya Tanaka, Isao Murata, “Development of Isotopically Enriched Boron-doped Alumina Dosimeter for Thermal Neutrons", Radiation Protection Dosimetry, 177[4], pp.475-480(2017).
2016
Fuminobu Sato, Tatsuro Maekawa, Tomoki Sakiyama, Naoki Zushi, Kikuo Shimizu, Yushi Kato, Isao Murata, Takayoshi Yamamoto, Toshiyuki Iida, “Development of human phantom containing radiophotoluminescence material”, Radiation Measurements, 85, pp.18-25 (2016).
Xingcai Guan, Masanobu Manabe, Shingo Tamaki, Shuangtong Liu, Fuminobu Sato, Isao Murata, Tieshan Wang, “Experimental study on the performance of an epithermal neutron flux monitor for BNCT”, Applied Radiation and Isotopes, 113, pp.28-32 (2016).
Xingcai Guan, Isao Murata, Tieshan Wang, “Design study of neutron flux intensity monitor between ten and several hundred keV for BNCT”, J. Nucl. Sci. Technol., 53[8], pp.1112-1119 (2016).
Masanobu Manabe, Soichiro Nakamura, Isao Murata, “Study on measuring device arrangement of array-type CdTe detector for BNCT-SPECT”, Reports of Practical Oncology and Radiotherapy, 21, pp.102-107 (2016).
Masanobu Manabe, Ryosuke Ohya, Nobuhide Saraue, Fuminobu Sato, Isao Murata, “Cross Talk Experiment with Two-element CdTe Detector and Collimator for BNCT-SPECT”, Journal of Radiation Protection and Research, 41(3), pp. 206-211 (2016).
Masami Ohnishi, Yasushi Yamamoto, Hodaka Osawa, Yuji Hatano, Yuji Torikai, Isao Murata, Keita Kamakura, Masaaki Onishi, Keiji Miyamoto, Hiroki Konda, Kai Masuda, Eiki Hotta, “Tritium burning in inertial electrostatic confinement fusion facility”, Fusion Eng. Des., 109-111, Part B, pp. 1709-1713 (2016).
Hiroyuki Takagi and Isao Murata, “Development of precise energy spectrum measurement technique for high-power pulsed X-ray sources for industrial use”, J. Nuclear Sci. Technol., 53[6], pp.766-773 (2016).
Hiroyuki Takagi and Isao Murata, “Energy Spectrum Measurement of High Power and High Energy (6 and 9 MeV) Pulsed X-ray Source for Industrial Use”, J. Radiation Protection and Research, 41[2], pp.93-99 (2016).
S. Ohnishi, S. Tamaki, I. Murata, “Validation of large-angle scattering data via shadow-bar experiment”, Fusion Eng. Des., 112, pp. 360-366 (2016).
Masanobu Manabe, Fuminobu Sato, Isao Murata, “Basic detection property of an array-type CdTe detector for BNCT?SPECT ? Measurement and analysis of anti-coincidence events”, Applied Radiation and Isotopes, 118, pp.389-394 (2016).
佐藤文信、日下祐江、前川達郎、山地恒輔、清水喜久雄、村田勲、山本幸佳、飯田敏行、”ラジオフォトルミネセンス線量計樹脂製の手ファントムの開発”、ESI-NEWS, 34[2], pp. 6-16 (2016).
日下祐江、吉岡順子、三宅陽治、伊達道淳、佐藤文信、村田勲、”大阪大学工学部における高校生向け放射線体験学習の取り組み”、ESI-NEWS, 34[3], pp. 3-10 (2016).
前川達郎、佐藤文信、村田勲、加藤裕史、“理工系学生を対象とする加速器科学入門のための教材”、応用物理教育、第40巻1号、pp.23-28 (2016).
奥村友紀、前川達郎、図子直城、佐藤文信、清水喜久雄、村田勲、加藤裕史、山本幸佳、飯田敏行、“ラジオフォトルミネセンス撮影による高線量場の空間線量分布測定”、日本放射線安全管理学会誌、第15巻1号、pp.40-45 (2016).
高木寛之、村田勲、藤井拓也、佐藤克利、上村博、佐藤正喜、橋本知之、森谷新一、木村俊哉、八木下剛、“再使用観測ロケットエンジン燃焼室の変形評価のための高分解能X線CT画像解析技術”、 Journal of JSNDI, 65[6], pp.277-286 (2016).
西谷健夫、今野力、佐藤聡、落合謙太郎、近藤恵太郎、村田勲、“最近の核融合中性子工学の進展 ４．核融合中性子源施設における中性子工学研究”、J. Plasma Fusion Res., 92[4], pp. 269-273 (2016).
吉岡潤子、日下祐江、三宅陽治、伊達道淳、佐藤文信、村田勲、“高校生向けの体験学習”ものづくり道場：放射線検出器を作ろう！”、日本放射線安全管理学会誌、第16巻1号、pp.25-28 (2017).(資料)
2015
I. Murata, Y. Otani, F. Sato, “Neutron intensity monitor with activation foil for p-Li neutron source for BNCT ? Feasibility test of the concept”, Applied Radiation and Isotopes, 106, pp.75-77 (2015).
村田 勲、”ホウ素中性子捕捉療法(BNCT)の工学研究”、TECHNO NET, 570, pp.5-18 (2015).
村田 勲、”大阪大学におけるp-液体Li中性子源を用いたホウ素中性子捕捉療法装置(CSePT)の開発と研究”、ESI-NEWS, 33[6], pp.1-13 (2015).
S. Tamaki, F. Sato, I. Murata, “A feasibility design study on a neutron spectrometer for BNCT with liquid moderator”, Applied Radiation and Isotopes, 106, pp.41-44 (2015).
S. Tamaki, M. Sakai, S. Yoshihashi, M. Manabe, N. Zushi, I. Murata, E. Hoashi, I. Kato, S. Kuri, S. Oshiro, M. Nagasaki, H. Horiike, “Mock-up experiment at Birmingham University for BNCT project of Osaka University ? Neutron flux measurement with gold foil”, Applied Radiation and Isotopes, 106, pp.72-74 (2015).
H. Horiike, I. Murata, T. Iida, S. Yoshihashi, E. Hoashi, I. Kato, N. Hashimoto, S. Kuri, S. Oshiro, “Liquid Li based neutron source for BNCT and science application”, Applied Radiation and Isotopes, 106, pp.92-94 (2015).
Xingcai Guan, Masanobu Manabe, Isao Murata, Tieshan Wang, “Design of an epi-thermal neutron flux intensity monitor with GaN wafer for boron neutron capture therapy”, J. Nucl. Sci. Technol., 52, pp. 503-508 (2015).
Fuminobu Sato, Naoki Zushi, Tomoki Sakiyama, Yushi Kato, Isao Murata, Kikuo Shimizu, Takayoshi Yamamoto, Toshiyuki Iida, “Radiophotoluminescence light scope for high-dose dosimetry”, Radiation Measurements, 82, pp.88-92 (2015).
2014
I. Murata, T. Obata, ” Boron Neutron Capture Therapy (BNCT) - Low-Energy Neutron Spectrometer for Neutron Field Characterization ?“, Plasma and Fusion Res., 9, 4401107 (2014).
I. Murata, S. Nakamura, M. Manabe, H. Miyamaru, I. Kato, “Characterization Measurement of A Thick CdTe Detector for BNCT-SPECT - Detection Efficiency and Energy Resolution -,” Applied Radiation and Isotopes, 88, pp. 129-133 (2014).
I. Murata, E. Tsuda, Ryotaro Nakamura, Shoko Nakayama, Masao Matsumoto, H. Miyamaru, “Neutron and gamma-ray source-term characterization of AmBe sources in Osaka University”, Progr. in Nucl. Sci. Technol., 4, pp. 345-348 (2014).
H. Miyamaru, I. Murata, R. Taniguchi, H. Shimomura, S. Okuda, “Gamma-ray transmission evaluation using imaging plate designed for X-ray radiography”, Progr. in Nucl. Sci. Technol., 4, pp. 699-703 (2014).
Fuminobu Sato, Naoki Zushi, Tatsuro Maekawa, Yushi Kato, Isao Murata, Kikuo Shimizu, Takayoshi Yamamoto, Toshiyuki Iida, “Visualization of high radiation field by radiophotoluminescence photography”, Radiation Measurements, 68, pp. 23-30 (2014).
C. Konno, I. Murata, ”Fusion Neutronics Source (FNS) Facility at Japan Atomic Energy Agency”, Compendium of Neutron Beam Facilities for High Precision Nuclear Data Measurements, IAEA-TECDOC-1743, pp. 119-128, International Atomic Energy Agency (2014).
S. Ohnishi, I. Murata, “Design of a new integral benchmark experiment for large angle scattering using shadow bar and DT neutron source”, Progr. in Nucl. Sci. Technol., 4, pp. 610-613 (2014).
Fuminobu Sato, Naoki Zushi, Tatsuro Maekawa, Yushi Kato, Isao Murata, Kikuo Shimizu, Takayoshi Yamamoto, Toshiyuki Iida, “Visualization of high radiation field by radiophotoluminescence photography”, Radiation Measurements, 68, pp. 23-30 (2014).
Itsuro Kato, Yusei Fujita, Masatoshi Ohmae, Yoshinori Sakurai, Minoru Suzuki, Shin-ichiro Masunaga, Isao Murata, Tetsuro Sumi, Mitsuhiro Nakazawa, Koji Ono, ” Boron neutron capture therapy in patients with recurrent head and neck cancers who have no other treatment options”, J Clin Oncol 32:5s, 2014 (suppl; abstr 6046)(2014).
M. Sakai, S. Tamaki, I. Murata, “Simplified Neutron Detector for Angular Distribution Measurement of p-Li Neutron Source”, Plasma and Fusion Research, 9, 4405111 (2014).
I. Murata, ”Intense 14 MeV Neutron Source Facility (OKTAVIAN) at Osaka University”, Compendium of Neutron Beam Facilities for High Precision Nuclear Data Measurements, IAEA-TECDOC-1743, pp. 110-118, International Atomic Energy Agency (2014).
I. Murata, S. Ohnishi, M. Manabe, R. Nakamura, H. Ito, S. Tamaki, X. Guan, S. Sato, A. Sukegawa, H. Morota, N. Hesham, A. Sagara, T. Muroga, T. Tanaka, “Study on Benchmark Experiment for Backward-Angle Scattering Reaction Cross Section at 14 MeV”, Annual Report of National Institute for Fusion Science April 2013 ? March 2014, p.347, ISSN 0917-1185, National Institute for Fusion Science (2014).
2013
I. Murata, Masayuki Ohta, “Performance analysis for neutronics benchmark experiments with partial adjoint contribution estimated by forward Monte Carlo calculation,” Fusion Eng. Des., 88, pp.2302-2305 (2013).
M. Sakai, N. Fujimoto, I. Murata, K. Awazu, “Development of Thermal Neutron Field with D-T Neutron Source Aiming at In Vivo and In Vitro Experiments for BNCT”, Housyasen, 38(4), 169 (2013).
2012
S. Ohnishi, K. Kondo, T. Azuma, S. Sato, K. Ochiai, K. Takakura, I. Murata, C. Konno, “New integral experiments for large angle scattering cross section data benchmarking with DT neutron beam at JAEA/FNS,” Fusion Engineering and Design, 87, 695-699 (2012).
Soichiro NAKAMURA, Taiki MUKAI, Masanobu MANABE, Isao MURATA, “Precise Numerical Simulation of Gamma-ray Pulse Height Spectrum Measured with a CdTe Detector Designed for BNCT-SPECT,” Progress in Nucl. Sci. Technol., 3, pp. 52-55 (2012).
2011
I. Murata, T. Mukai, S. Nakamura, H. Miyamaru, I. Kato, “Development of A Thick CdTe Detector for BNCT-SPECT,” Appl. Radiat. Isotopes, 69, pp. 1706-1709 (2011).
I. Murata, T. Mukai, M. Ito, H. Miyamaru, S. Yoshida, “Feasibility study on BNCT-SPECT using a CdTe detector,” Progress in Nucl. Sci. Technol., 1, pp. 267-270 (2011).
I. Murata, M. Ohta, H. Miyamaru, K. Kondo, S. Yoshida, T. Iida, K. Ochiai, C. Konno, “Performance Analysis of Fusion Nuclear-data Benchmark Experiments for Light to Heavy Materials in MeV Energy Region with A Neutron Spectrum Shifter,” J. Nucl. Mater., 417, pp. 1127-1130 (2011).
K. Kondo, I. Murata , K. Ochiai, N. Kubota, H. Miyamaru, C. Konno, T. Nishitani, “Measurement of Charged-Particle Emission Double-Differential Cross Section of Fluorine for 14.2 MeV Neutrons”, Journal of Nuclear Science and Technology, 48[8], pp. 1146?1157 (2011).
M. Matsumoto, M. Takashina, S. Nakayama, I. Murata, “Evaluation of Performance and Response Function to 10 MeV of New NaI(Tl) Scintillation Detector,” Igaku Butsuri, 31, p. 201 (2001).
M. Sakai, N. Fujimoto, K. Ishii, I. Murata, K. Awazu, “Thermal neutron field with D-T neutron source for BNCT,” Progress in Nucl. Sci. Technol., 1, pp. 513-516 (2011).
S. Yoshida, K. Yamahana, H. Matsue, I. Murata, “Nondestructive Analysis of the Ancient Egyptian Vitreous Relics by Neutron,” Progress in Nucl. Sci. Technol., 1, pp. 259-262 (2011).
H. Miyamaru, I. Murata, “Neutron and Gamma-ray Dose Evaluation on Accelerator Neutron Source using p-Li Reaction for BNCT,” Progress in Nucl. Sci. Technol., 1, pp. 533-536 (2011).
W. Kada, N. Dwaikat, M. Sueyasu, J. Datemichi, F. Sato, I. Murata, Y. Kato, T. Iida, “Development of a Grab-sampling Type Multitubular Proportional Counter for Measurement of Radon Concentration in Atmospere,” Progress in Nucl. Sci. Technol., 1, pp. 396-399 (2011).
S. Yoahida, I. Murata, T. Nakagawa, I. Saito, “Analysis of the Propagation of Neutrons and Gamma-rays from the Fast Neutron Source Reactor YAYOI,” J. Nucl. Mater., 417, pp.1345-1347 (2011).
S. Ohnishi, K. Kondo, S. Sato, K. Ochiai, K. Takakura, I. Murata, C. Konno, “Implementation of A DT Neutron Beam at the 1st Target Room of JAEA/FNS for New Integral Benchmark Experiments,” J. Korean Phys. Soc., 59[2], pp. 1949-1952 (2011).
D. Maki, F. Sato, I. Murata, Y. Kato, Y. Tanimura, T. Yamamoto, T. Iida, “Development of neutron-sensitive glass dosimeter containing isotopically enriched boron,” Radiation Measurements, 46, pp. 1484-1487 (2011).
2010
Murata, “High-precision Measurements of Nuclear Data with Beam DT-Neutrons,” Proc. of the 2009 Annual Symposium on Nucl. Data (NDS 2009), Nov. 26-27, 2009, RICOTTI, Tokai-mura, Ibaraki-ken, Japan, JAEA-Conf 2010-005, pp.15-20 (2010). (invited)
T. Kuchimaru, F. Sato, S. Tanaka, I. Murata, Y. Kato, T. Iida, “Development of Cell Chip Based on Track Detector for Examination of Biological Damage by Alpha Particles,” J. Nucl. Sci. Technol., 47[12], 1206-1210 (2010).
W. Kada, N. Dwaikat, J. Datemichi, F. Sato, I. Murata, Y. Kato, T. Iida, “A twin-type airflow pulse ionization chamber for continuous alpha-radioactivity monitoring in atmosphere,” Radiation Measurements, 45, 1044-1048 (2010).
S. Yoshida, T. Ebihara, T. Yano, A. Kozlov, T. Kishimoto, I. Ogawa, R. Hazama, S. Umehara, K. Mukaida, K. Ichihara, Y. Hirano, I. Murata, J. Datemichi, H. Sugimoto, “Light output response of KamLAND liquid scintillator for protons and 12C nuclei,” Nucl. Instrum. Meth. in Phys. Res., A622, 574(2010).
D. Maki, F. Sato, I. Murata, Y. Kato, T. Yamamoto, T. Iida, “Performance of Convenient Film Scanner System for Automatic Counting of Track Etched Pits on PADC Detectors,” Radiation Safety Management, 9[1], 1-6 (2010).
D. Maki, H. Kobayashi, F. Sato, I. Murata, Y. Kato, T. Yamamoto, T. Iida, “New Radiophotoluminescence Glass Dosimeter with Specialized Radiation-Sensitive Surface Layer,” J. J. App. Phys., 49, 116401 (2010).
K. Shimada, N. Nakanii, I. Murata, H. Habara, K. A. Tanaka, “Measurement of Fast Neutron by Using Imaging Plate,” J. Phys.: Conf. Ser. 244, 032059 (2010).
伊達道淳、吉岡潤子、杉本久司、村田勲、飯田敏行、“大阪大学工学系技術職員研修のための放射線実習用空気比例計数管の製作”、日本放射線安全管理学会誌、第9巻2号、pp. 141-146 (2010).
Awards
2020
2019
Yuri Morizane(Osaka university sophomore、supervisor Osaka University Professor Murata)、"The fiscal year 1990 voluntary research promotion project" excellence award、May.2.2019
Takuya Nishida, Best Poster Award, The 16th Annual Meeting of the Japanese Society for Neutron Capture Therapy
Haruka Inamoto, Fellow Award for year 2019, Atomic Energy Society of Japan, Mar. 2019.
For excellent grade about nuclear and radiation of bachelor course
2018
Saki Shibata, Fairchild Award, The 18th International Congress on Neutron Capture Therapy(ICNCT-18),Nov.12,2018
2017
Yuri Morizane (Otemae High School grade3、Teacher: Osaka University Professor Murata)、Japan Science and Technology Agency (JST) President's Award、「Global Science Campus(GSC)」2017 National Student Study Presentation (JST)、Oct 8, 2017
Xingcai Guan, JNST Most Popular Article Award for year 2017, Atomic Energy Society of Japan(Journal of Nuclear Science and Technology), Apr. 7, 2018.
For their paper entitled "Design of an epi-thermal neutron flux intensity monitor with GaN wafer for boron neutron capture therapy"
" Design of an epi-thermal neutron flux intensity monitor with GaN wafer for boron neutron capture therapy "
Ryousuke Ohya, Fellow Award for year 2018, Atomic Energy Society of Japan, Mar. 27, 2018.
For excellent grade about nuclear and radiation of master course
Ryota Yamauchi, Fellow Award for year 2018, Atomic Energy Society of Japan, Mar. 27, 2018.
For excellent grade about nuclear and radiation of bachelor course
2016
Xingcai Guan, JNST Most Popular Article Award for year 2016, Atomic Energy Society of Japan(Journal of Nuclear Science and Technology), Dec. 31, 2016.
For their paper entitled "Design of an epi-thermal neutron flux intensity monitor with GaN wafer for boron neutron capture therapy"
" Design of an epi-thermal neutron flux intensity monitor with GaN wafer for boron neutron capture therapy "
Yasuhiro Nishiyama, Poster Presentation Award, 2016 Symposium on Nuclear Data, High Energy Accelerator Research Organization, Tokai,Japan, Nov. 18-19, 2016.
For their paper entitled "Nondestructive Determination of Water Content in Concrete by Foil Activation Method -Feasibillity study by Numerical Simulation-"
" Nondestructive Determination of Water Content in Concrete by Foil Activation Method -Feasibillity study by Numerical Simulation- "
2015
Nobuhide Saraue, Poster Presentation Award, 2015 Symposium on Nuclear Data, Ibaraki Quantum Beam Reserch Center, Tokai,Japan, Nov. 19-20, 2015.
For their paper entitled "Contribution from Gd capture gamma-ray in GAGG based SPECT for boron neutron capture therapy"
" Contribution from Gd capture gamma-ray in GAGG based SPECT for boron neutron capture therapy "
Naoya Hayashi,Poster Presentation Award, 2015 Symposium on Nuclear Data, Ibaraki Quantum Beam Reserch Center, Tokai,Japan, Nov. 19-20, 2015.
For their paper entitled "Optimizzation of experimental system design for benchmarking of large angle scattering reaction cross section at 14MeV using a shadow bar"
" Optimizzation of experimental system design for benchmarking of large angle scattering reaction cross section at 14MeV using a shadow bar "
2014
Masanobu Manabe, Ralph Fairchild Award, International Society for Neutron Capture Therapy, Helsinki, Finland, Jun. 14-19, 2014.
To young scientist. For making significant contribution to the development of neutron capture therapy. With the high-lighted abstract : " Basic property of array-type CdTe detector for BNCT-SPECT "
" Basic property of array-type CdTe detector for BNCT-SPECT "
Shingo Tamaki, Ralph Fairchild Award, International Society for Neutron Capture Therapy, Helsinki, Finland, Jun. 14-19, 2014.
To young scientist. For making significant contribution to the development of neutron capture therapy. With the high-lighted abstract : " Design of A New Wide-dynamic-range Neutron Spectrometer for BNCT with Liquid Moderator and Absorber "
" Design of A New Wide-dynamic-range Neutron Spectrometer for BNCT with Liquid Moderator and Absorber "
Guan Xingcai, BEST PRESENTATION AWARD, The 11th Congress on Neutron Capture Therapy, Osaka, Japan, Jul.6,2014.
" Design of neutron flux intensity monitor between 10 and several hundred keV with GaN wafer for BNCT "
" Design of neutron flux intensity monitor between 10 and several hundred keV with GaN wafer for BNCT "
2013
Shingo Tamaki, Best Poster Presentation Award, 2013 Symposium on Nuclear Data, Research Institute of Nuclear Engineering University of Fukui, Tsuruga, Fukui, Japan, Nov. 14-15, 2013.
For their paper entitled by " Feasibility study on high-dynamic-range neutron spectrometer with continuously thick-adjustable moderator/absorber "
"Feasibility study on high-dynamic-range neutron spectrometer with continuously thick-adjustable moderator/absorber"
2010
Masao Ito, Poster Presentation Award, 2010 Symposium on Nuclear Data, Kyushu University, Kasuga, Fukuoka, Japan, Nov. 25-26, 2010.
For their paper entitled "Thermal/epi-thermal neutron spectrometer with a 3Heposition sensitive proportional counter"
" Thermal/epi-thermal neutron spectrometer with a 3Heposition sensitive proportional counter "
2009
Taiki Mukai, Poster Presentation Award, 2009 Symposium on Nuclear Data, RICOTTI Convention Center, Tokai, Japan, Nov. 26-27, 2009.
For their paper entitled " Development of CdTe detector for BNCT-SPECT "
" Development of CdTe detector for BNCT-SPECT "